It’s best to handle your collectible coins as little as possible. When collectible coins are handled you run the risk of them being nicked, scratched, or dirty and their value is lessened. When it's absolutely necessary you should hold them on the edges.

Coin cleaning, which is not recommended, should be handled by a specialist. Collectors might actually value the patina a coin has gradually developed, and consider a cleaned coin less desirable.

Moisture can cause problems just like fingerprints and dust can, so even though most holders are sufficient to protect your buffalo nickels make sure your most valuable pieces are really protected. Stapled or taped packets don’t give maximum protection, but there are other protectors in the market that can also guard effectively against moisture. Protecting your collectible coins from water damage is paramount; choose a dry, controlled-temperature space, never a damp basement or cellar.